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pentobarbital will minimize the level or impact of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Sturdy CYP3A4 inducers may lower midostaurin concentrations causing lowered efficacy.pentobarbital will reduce the extent or result of bortezomib by impacting hepatic/intestinal enzyme CYP3